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MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscl
MicroRNAs can regulate the function of ion channels in many organs. Based on our previous study we propose that miR-142a......
Effect of Electroacupuncture on the Pathomorphology of the Sciatic Nerve and the Sensitization of P2
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Study on the effect of Neuropeptide(Nesfatin-1)on epileptic discharges in rat insular cortex neurons
Nesfatin-1 is the discovered peptide hormones involved in the control of appetite in 2006....
Bulleyaconitine A blocks voltage-gated sodium channels in dorsal root ganglion neuron and attenuates
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Activation of medullary a1A-adrenoceptors increases airway vagal tone via enhanced excitatory inputs
In mammals including the human beings,the neural control of airway smooth muscles is dominated by medullary airway vagal......
AIM The purpose of this study was to study the influence of KCNE4 on potassium ion channel KCNQ 1 and HERG.Method We con......
Activation of cannabinoid type Ⅱ receptors modulates T-type voltage-gated calcium channels in rat re
Endocannabinoid signaling is involved in regulating multiple neuronal functions in the central nervous system,by activat......
Arginine vasopressin regulates the medullary airway vagal preganglionic neurons via the V1a-receptor
The cholinergic pathway or central vagal excitation has been found to be involved in the bronchoconstriction and the inc......
Dopaminergic differential regulation of beta oscillatory dynamics through modulation of Kir channels
Objective The dorsal striatum plays a key role in motion function and disease,psychiatric disorders.Proper functioning o......
The first-generation antihistamines are widely prescribed medications to relieve allergic reactions and urticaria by blo......
Exercise training changes the gating properties of large-conductance Ca2+-activated K+ channels in a
Objective: Physical inactivity and ageing are widely recognized as risk factors for the development of cardiovascular di......
Differential alterations in the morphology and electrophysiology of layer Ⅱ pyramidal cells in the p
Maternal inflammation is a known risk factor for schizophrenia and autism.Since the visual processing has shown abnormal......
Anterior auditory field(AAF)and primary auditory cortex(A1)constitute the core region of auditory cortex yet how the inf......
Arginine vasopressin enhances the synaptic inputs of medullary airway vagal preganglionic neurons vi
The airway vagal preganglionic neurons(AVPNs)supply the major cholinergic output to the trachea and bronchus.AVP-contain......
Auditory cortical neurons exhibit relatively large variation in their spiking responses to sound stimuli,reflected in th......
The anti-nociceptive effect of bufalin, an active ingredient from toad venom via modulating voltage-
OBJECTIVE Toad venom (Venenum Bufonis) isalways used for analgesia in China from ancient to modern times, but the effect......
Functional Changes of TREK-1 Potassium Channel in Ventricular Myocytes During Rat Cardiac Hypertroph
Aim: Two pore domain potassium channel TREK-1 has been shown to present in the mammalian heart, but the role of TREK-1 i......
Calcium-activated Chloride Channels (CaCCs), TMEM16A, control diverse functions in nociception, neuronal excitability, m......
Objective: Large-conductance Ca2+-activated potassium channels (BKCa) are widely expressed in central neuron system, inc......
Effects of astragaloside Ⅳ on action potentials and ionic currents in Guinea pig ventricular myocyte
AIM AstragalosideⅣ (AS-Ⅳ) is one of the main active constituents of astragalus membranaceus, the present study is to i......
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目的观察单独及联合使用延胡索乙素和2人参皂苷Re 对大鼠心室肌 细胞L-型钙通道的影响。方法采用急性酶解分离法获得大鼠的单个心......
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Effect of etomidate on voltage-dependent potassium currents in rat isolated hippocampal pyramidal ne
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Morphological and electrophysiological properties of single myocardial cells from Koch triangle of r
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Propofol enhances the field excitatory postsynaptic potentials in CA1 hippocampal slices of young an
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Voltage-gated calcium channels(VGCCs)control a plethora of physiological processes,from muscle contraction,heartbeat......
1.It is reported that bitter tastants decrease blood pressure and relax precontracted vascular smooth muscle.However......
Inhibition of human ether à go-go (hEAG1) potassium channel by Phosphatidylinositol-4,5-bisphosphate
Human ether à go-go (hEAG) channels are important for tumor development and have been recognized as a potential therape......
Among the nine VGSC subtypes, Nav1.7 and Nav1.8 are attractive therapeutic targets for pains.However, the heterologo......
Effect of orphanin FQ and morphine on sodium channel current in somatosensory area of rat cerebral c
BACKGROUND: Some experiments have demonstrated that injecting orphanin FQ (OFQ) into lateral ventricle, which can obviou......
Catilan extracted from Leiurus quinquestriatus is a specific ion channel blocker.It can specifically bind chloride chann......
In vivo field recordings effectively monitor the mouse cortex and hippocampus under isoflurane anest
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目的 观察奎宁和甘珀酸对肠系膜动脉平滑肌细胞间缝隙连接通道的影响,为探索强效缝隙连接阻断药提供实验依据.方法 采用全细胞膜片......
Effect of Chengzai Pill on the L-Type Ca2+ Channel Currents of Osteoblasts Pretreated with Methylpre
Objective: To observe the effect of the serum containing Chengzai Pill on the L-type voltage-sensitive calcium channels ......
AIM: To record calcium and potassium currents in acutely isolated smooth muscle cells of mesenteric arterial branches in......
nflammatory response during damage and necrosis in AMs induced by exposure to quartz particle. K+ channels do not contri......
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Effect of Chengzai Pill on the L-Type Ca2+ Channel Currents of Osteoblasts Pretreated with Methylpre
Objective: To observe the effect of the serum containing Chengzai Pill on the L-type voltage-sensitive calcium channels ......
Effect of orphanin FQ and morphine on sodium channel current in somatosensory area of rat cerebral c
BACKGROUND: Some experiments have demonstrated that injecting orphanin FQ (OFQ) into lateral ventricle, which can obviou......
EFFECTS OF GLUTAMATE ON SODIUM CHANNEL IN ACUTELY DISSOCIATED HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF R
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
EFFECTS OF GLUTAMATE ON SODIUM CHANNEL IN ACUTELY DISSOCIATED HIPPOCAMPAL CA1 PYRAMIDAL NEURONS OF R
Objective To observe the effects of glutamate on sodium channel in acutely dissociated hippocampal CAI pyramidal neurons......
目的通过研究阿托伐他汀预处理对兔急性心肌梗死后1周心室肌细胞L-钙离子通道电流（I Ca-L）的影响，探讨他汀类药物抗心律失常的细胞学......
目的:观察氯通道阻断药5-硝基-2(3-苯丙胺)-苯甲酸(NPPB)和他莫昔芬对小鼠心室肌容积敏感性氯通道的影响. 方法:采用急性分离的小......
目的:建立适合于研究肌肉松驰药作用的乙酰胆碱受体的实验模型.方法:采用磁珠技术从大鼠肌肉中提取多聚腺嘌呤mRNA,注入去膜的非洲......
目的:研究吗啡对新生鼠尾核神经元钾离子通道电流的作用.方法:应用全细胞膜片钳技术在培养的尾核神经元上,观察吗啡急性与慢性处理......
目的：研究大鼠肺内动脉平滑肌细胞钾电流。方法 用急性酶解分离法得到单个大鼠肺内动脉平滑肌细胞，采用膜片钳全细胞记录方式研究钾......
